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Chronic recurrent multifocal osteomyelitis in children with hypophosphatasia explained by anti-inflammatory nucleotidase activity of tissue nonspecific alkaline phosphatase in mesenchymal and hematopoietic cells

Archive ouverte | Bessueille, Laurence | CCSD

International audience

Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase

Archive ouverte | Bessueille, Laurence | CCSD

International audience. Tissue-nonspecific alkaline phosphatase (TNAP) is necessary for skeletal mineralization by its ability to hydrolyze the mineralization inhibitor inorganic pyrophosphate (PPi), which is mainly...

Alkaline phosphatase multi-tasks in the brain

Archive ouverte | Fonta, C | CCSD

International audience. Introduction: There are several genes for alkaline phosphatase (AP). One of them codes for TNAP (Tissue Non-specific Alkaline Phosphatase). It is a ubiquitous ectoenzyme located in different ...

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