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The phosphoinositide-binding protein TRAF4 modulates tight junction stability and migration of cancer cells

Archive ouverte | Rousseau, Adrien | CCSD

International audience. Tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4), a protein localized in TJs in normal epithelial cells, is frequently overexpressed in carcinomas. We recently found that TRAF...

STARD3/STARD3NL and VAP make a novel molecular tether between late endosomes and the ER

Archive ouverte | Alpy, Fabien | CCSD

International audience. Inter-organelle membrane contacts sites (MCSs) are specific subcellular regions favoring the exchange of metabolites and information. We investigated the potential role of the late-endosomal ...

TRAF4 Is a Novel Phosphoinositide-Binding Protein Modulating Tight Junctions and Favoring Cell Migration

Archive ouverte | Rousseau, Adrien | CCSD

International audience. Tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) is frequently overexpressed in carcinomas, suggesting a specific role in cancer. Although TRAF4 protein is predominantly found...

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