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A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals major role of BAX in BH3 mimetics response

Archive ouverte | Durand, Romane | CCSD

International audience. To establish a strict p53-dependent gene expression profile, TP53-/- clones were derived from TP53+/+ and TP53-/mut t(4;14) human myeloma cell lines (HMCLs) using CRISPR/Cas9 technology. From...

BH3 profiling as a tool to identify acquired resistance to venetoclax in multiple myeloma

Archive ouverte | Dousset, Christelle | CCSD

International audience. BH3 profiling as a tool to identify acquired resistance to venetoclax in multiple myeloma Venetoclax/ABT-199 is the first in the class of BCL2-specific BH3 mimetics and the most promising tar...

Combined inhibition of CTPS1 and ATR is a metabolic vulnerability in p53‐deficient myeloma cells

Archive ouverte | Durand, Romane | CCSD

International audience. Abstract In multiple myeloma, as in B‐cell malignancies, mono‐ and especially bi‐allelic TP53 gene inactivation is a high‐risk factor for treatment resistance, and there are currently no ther...

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