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Association of critically short telomeres with brain and blood markers of ageing and Alzheimer’s disease in older adults

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Lehodey, Asrar | Kaliman, Perla | Palix, Cassandre | de Florès, Robin | de Flores, Robin | Touron, Edelweiss | Turpin, Anne-Laure | Fauvel, Séverine | Mézenge, Florence | Mezenge, Florence | Landeau, Brigitte | Chocat, Anne | Vrillon, Agathe | Paquet, Claire | Vivien, Denis | de La Sayette, Vincent | Chételat, Gaël | Poisnel, Géraldine | André, Claire | Arenaza-Urquijo, Eider | Champetier, Pierre | Colette, Fabienne | Delarue, Marion | Felisatti, Francesca | Devouge, Egantine Ferrand | Garnier-Crussard, Antoine | Gonneaud, Julie | Heidmann, Marc | Jessen, Frank | Klimecki, Olga | Kuhn, Elizabeth | Le Du, Gwendoline | Lefranc, Valérie | Lutz, Antoine | Marchant, Natalie | Moulinet, Inès | Ourry, Valentin | Paly, Léo | Poletti, Stefano | Quillard, Anne | Rauchs, Géraldine | Rehel, Stéphane | Salmon, Eric | Sherif, Siya | Vanhoutte, Matthieu | Vuilleumier, Patrik | Ware, Caitliin | Wirth, Miranka

Edité par CCSD ; BioMed Central -

International audience. Accumulation of critically short telomeres (CST) is implicated in decreased tissular regenerative capacity and increased susceptibility to degenerative diseases such as Alzheimer's disease (AD). Telomere shortening has also been associated with age-related brain changes. However, it remains unclear whether CST accumulation is directly associated with AD markers or instead amplifies age-related effects, potentially increasing susceptibility of developing AD in cognitively healthy older adults.

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