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VULNERABILITY OF PROGEROID SMOOTH MUSCLE CELLS TO ARTERIAL SHEAR STRESS IS MEDIATED BY MMP13

Archive ouverte | Pitrez, Patricia | CCSD

International audience. Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, alt...

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Archive ouverte | Pitrez, Patricia, R | CCSD

International audience. Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, alt...

Substrate Topography Modulates Cell Aging on a Progeria Cell Model

Archive ouverte | Pitrez, Patricia R. | CCSD

International audience. Aging is characterized by a progressive accumulation of cellular damage, which leads to impaired function. Little is known whether substrates can influence cell aging. This is of utmost impor...

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