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Liquid Biopsies for Circulating Tumor DNA Detection May Reveal Occult Hematologic Malignancies in Patients With Solid Tumors

Archive ouverte | Aldea, Mihaela | CCSD

International audience. PURPOSE High-risk clonal hematopoiesis (CH) is frequently incidentally found in patients with solid tumors undergoing plasma cell–free DNA sequencing. Here, we aimed to determine if the incid...

Clinical utility of circulating tumor DNA sequencing with a large panel: a National Center for Precision Medicine (PRISM) study

Archive ouverte | Bayle, Arnauld | CCSD

International audience. Background: Circulating tumor DNA (ctDNA) sequencing is a promising approach for tailoring therapy in patients with cancer. We report hereby the results from a prospective study where we inve...

Genomic landscape of liquid biopsy mutations in TP53 and DNA damage genes in cancer patients

Archive ouverte | Vasseur, Damien | CCSD

International audience. Abstract Next-generation sequencing (NGS) assays based on plasma cell-free DNA (cfDNA) are increasingly used for clinical trials inclusion. Their optimized limit of detection applied to a lar...

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