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Assessing metastatic potential of patients' renal carcinoma on a chip: ONCOTRAP

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Filhol, Odile | Cesana, Beatrice | Séraudie, Irinka | Pillet, Catherine | Lambert, Elisa | Kaal, Joris | Descotes, Jean-Luc | Migliorini, Elisa | Cochet, Claude

Edité par CCSD -

International audience. Clear cell Renal Cell Carcinoma (ccRCC) is one of the most prevalent kidney cancers, which is often asymptomatic and thus discovered at a metastatic state (mRCC). mRCC are highly heterogeneous tumors composed of subclonal populations that lead to poor treatment response rate. Several recent works explored the potential of ccRCC tumoroids culture derived from patients. Following the observation that ccRCC tumoroids can create their own niche by secreting extracellular matrix components, we developed the first scaffold-free tumoroid model of ccRCC tumors. This model enables to evaluate invasiveness of renal cancer cells in a 3D context toward a metastatic niche. Inserted into a chip named ONCOTRAP, these tumoroids provide also a robust preclinical test to study metastatic process.

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