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Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

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Motta, Jean-Paul | Bermúdez-Humarán, Luis | Deraison, Céline | Martin, Laurence | Rolland, Corinne | Rousset, Perrine | Boue, Jérôme | Dietrich, Gilles | Chapman, Kevin | Kharrat, Pascale | Vinel, Jean-Pierre | Alric, Laurent | Mas, Emmanuel | Sallenave, Jean-Michel | Langella, Philippe | Vergnolle, Nathalie

Edité par CCSD ; American Association for the Advancement of Science (AAAS) -

International audience. Lactic acid–producing bacteria engineered to produce the antiprotease Elafin restore colon homeostasis in mice with colitis and protect human tissue from inflammation.

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Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

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Elafin, a natural protease inhibitor expressed in healthy intestinal mucosa, has pleiotropic anti-inflammatory properties in vitro and in animal models. We found that mucosal expression of Elafin is diminished in patients with inf...

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Background: Different studies have described the successful use of recombinant lactic acid bacteria (recLAB) to deliver anti-inflammatory molecules at the mucosal level to treat Inflammatory Bowel Disease (IBD). Methods: In order ...

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