Autoantibodies against type I IFNs in patients with critical influenza pneumonia
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Zhang, Qian | Pizzorno, Andrés | Miorin, Lisa | Bastard, Paul | Gervais, Adrian | Le Voyer, Tom | Bizien, Lucy | Manry, Jeremy | Rosain, Jérémie | Philippot, Quentin | Goavec, Kelian | Padey, Blandine | Cupic, Anastasija | Laurent, Emilie | Saker, Kahina | Vanker, Martti | Särekannu, Karita | Abel, Laurent | Aiuti, Alessandro | Al-Muhsen, Saleh | Al-Mulla, Fahd | Anderson, Mark | Andreakos, Evangelos | Arias, Andrés | Baris Feldman, Hagit | Belot, Alexandre | Biggs, Catherine | Bogunovic, Dusan | Bolze, Alexandre | Bondarenko, Anastasiia | Bousfiha, Ahmed | Brodin, Petter | Bryceson, Yenan | Bustamante, Carlos | Butte, Manish | Casari, Giorgio | Christodoulou, John | Condino-Neto, Antonio | Constantinescu, Stefan | Cooper, Megan | Dalgard, Clifton | Desai, Murkesh | Drolet, Beth | El Baghdadi, Jamila | Espinosa-Padilla, Sara | Fellay, Jacques | Flores, Carlos | Fragkou, Paraskevi | Franco, José Luis | Froidure, Antoine | Galani, Ioanna Evdokia | Gregersen, Peter | Grimbacher, Bodo | Haerynck, Filomeen | Hagin, David | Halwani, Rabih | Hammarström, Lennart | Heath, James | Henrickson, Sarah | Hsieh, Elena W.Y. | Husebye, Eystein | Imai, Kohsuke | Itan, Yuval | Jarvis, Erich | Karamitros, Timokratis | Kisand, Kai | Koltsida, Ourania | Ku, Cheng-Lung | Lau, Yu-Lung | Ling, Yun | Lucas, Carrie | Maniatis, Tom | Mansouri, Davood | Maródi, László | Meyts, Isabelle | Milner, Joshua | Mironska, Kristina | Mogensen, Trine | Morio, Tomohiro | Ng, Lisa F.P. | Notarangelo, Luigi | Novelli, Antonio | Novelli, Giuseppe | O'Farrelly, Cliona | Okada, Satoshi | Okamoto, Keisuke | Ozcelik, Tayfun | Pan-Hammarström, Qiang | Pape, Jean | Perez de Diego, Rebeca | Perlin, David | Pesole, Graziano | Planas, Anna | Prando, Carolina | Pujol, Aurora | Quintana-Murci, Lluis | Ramaswamy, Sathishkumar | Rapti, Vasiliki | Renia, Laurent | Resnick, Igor | Rodríguez-Gallego, Carlos | Rovina, Nikoletta | Sancho-Shimizu, Vanessa | Sediva, Anna | Seppänen, Mikko R.J. | Shahrooei, Mohammed | Shcherbina, Anna | Slaby, Ondrej | Snow, Andrew | Soler-Palacín, Pere | Spaan, András | Tancevski, Ivan | Tangye, Stuart | Abou Tayoun, Ahmad | Temel, Şehime Gülsün | Tsiodras, Sotirios | Turvey, Stuart | Uddin, K.M. Furkan | Uddin, Mohammed | van de Beek, Diederik | Vinh, Donald | von Bernuth, Horst | Wauters, Joost | Zatz, Mayana | Zawadzki, Pawel | Su, Helen | Casanova, Jean-Laurent | Morel, Pascal | Richard, Pascale | Bonneaudeau, Brigitte | Cannet, Dorothée | Gallian, Pierre | Jeanne, Michel | Perroquin, Magali | Hamzeh-Cognasse, Hind | Cognasse, Fabrice | Tiberghien, Pierre | Nadif, Rachel | Goldberg, Marcel | Ozguler, Anna | Henny, Joseph | Lemonnier, Sylvie | Coeuret-Pellicer, Mireille | Le Got, Stéphane | Zins, Marie | Tzourio, Christophe | Debette, Stéphanie | Dufouil, Carole | Soumaré, Aïcha | Lachaize, Morgane | Fievet, Nathalie | Flaig, Amandine | Martin, Fernando | Mehlal-Sedkaoui, Souad | Sallette, Jérôme | Hernu, Romain | Lina, Bruno | Schwebel, Carole | Wroblewski, Isabelle | Morand, Patrice | Souweine, Bertrand | Boeuf, Benoit | Peigue-Lafeuille, Helene | Darmon, Michael | Patural, Hugues | Pozzetto, Bruno | Quenot, Jean Pierre | Colomb, Benoit | Pothier, Pierre | Abad Arranz, Maria | Aguilar Guisado, Manuela | Escoresca Ortega, Ana | Gallardo Ríos, Rafaela | Merino Díaz, Laura | del Mar Muñoz Garcia, Maria | Ramírez Duque, Nieves | Romero Vázquez, Gloria María | Sánchez Cordero, Maria Jose | Salamanca Rivera, Celia | Niubó, Jordi | Rombauts, Alexander | Navarrete, Nicolás | Romero Oraa, Laura | Palomo, Virginia | García-Salum, Tamara | Ferres, Marcela | Le Corre, Nicole | Sánchez-Céspedes, Javier | Balsera-Manzanero, María | Carratala, Jordi | Retamar-Gentil, Pilar | Abelenda-Alonso, Gabriela | Valiente, Adoración | Castagnoli, Riccardo | Gonzalez-Granado, Luis | Dominguez-Pinilla, Nerea | Triantafyllia, Vasiliki | Solé-Violán, Jordi | Ruiz-Hernandez, José Juan | Rodríguez de Castro, Felipe | Ferreres, José | Briones, Marisa | Vanderbeke, Lore | Feys, Simon | Kuo, Chen-Yen | Lei, Wei-Te | Tal, Galit | Etzioni, Amos | Hanna, Suhair | Fournet, Thomas | Casalegno, Jean-Sebastien | Queromes, Gregory | Argaud, Laurent | Javouhey, Etienne | Rosa-Calatrava, Manuel | Cordero, Elisa | Aydillo, Teresa | Medina, Rafael | Puel, Anne | Jouanguy, Emmanuelle | Cobat, Aurélie | Trouillet-Assant, Sophie | García-Sastre, Adolfo
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CCSD ; Rockefeller University Press -
International audience.
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6–73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-α2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-ω. The patients’ autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 × 10−5), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-α2 and IFN-ω (OR = 11.7, P = 1.3 × 10−5), especially those <70 yr old (OR = 139.9, P = 3.1 × 10−10). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for ∼5% of cases of life-threatening influenza pneumonia in patients <70 yr old.
