Syracuse

Electrogenerated chemiluminescence, also called electrochemiluminescence (ECL), has attracted much attention in various fields of analysis due to its high sensitivity, extremely wide dynamic range and excellent control in space and time of the light emission. The great success of ECL for in vitro detection results from the advantages combining the selectivity of the biological recognition elements and the sensitivity and controllability of ECL technology. ECL is widely applied as a powerful analytical technique for ultrasensitive detection of biomolecules. In this review, we summarize the recent developments and applications of ECL for immunosensing. Herein, we present the sensing schemes and the applications in different area, such as detection of biomarkers, bead-based detection, bacteria and cell analysis and give future perspectives for new developments in ECL immunosensing. In particular, ECL based sensing assays for clinical samples analysis and medical diagnostics and developing of immunosensors for this purpose are highlighted.