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Characterization of IL-6 and GDF15 expression during the transition from pre-anorexia to anorexia in the C26 tumor-bearing mouse model

Archive ouverte | Chaouki, Ghita | CCSD

International audience. Introduction: Anorexia is a major symptom of cachexia for a large number of cancer patients, disrupting the physiological regulation of food intake and contributing to the deterioration of he...

Pre-cachectic changes in amino acid homeostasis precede activation of eIF2α signaling in the liver at the onset of C26 cancer-induced cachexia

Archive ouverte | Chaouki, Ghita | CCSD

International audience. The sequence of events associated with cancer cachexia induction needs to be further characterized. Using the C26 mouse model, we found that prior to cachexia, cancer progression was associat...

Induction of ATF4-Regulated Atrogenes Is Uncoupled from Muscle Atrophy during Disuse in Halofuginone-Treated Mice and in Hibernating Brown Bears

Archive ouverte | Cussonneau, Laura | CCSD

International audience. Activating transcription factor 4 (ATF4) is involved in muscle atrophy through the overexpression of some atrogenes. However, it also controls the transcription of genes involved in muscle ho...

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