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NUCLEOLIN: Similar and Antagonistic Roles in Arabidopsis thaliana

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Durut, Nathalie | Abou-Ellail, Mohamed | Comella, Pascale | Jobet, Edouard | Debures, Anne | Sáez-Vásquez, Julio

Edité par CCSD -

International audience. NUCLEOLIN (NUC) is an evolutionary conserved and multifunctionary protein present in all eukaryotic cells. NUC is a major nucleolar protein involved in ribosome biogenesis, including RNA Pol I transcription and processing of 45S pre-rRNA and assembly and transport of ribosome particles to the cytoplasm. Noteworthy, NUC protein is involved also in the control of RNA pol II transcription and other activities in the nucleoplasm. NUC protein is encoded by a single gene in yeast (NSR1/ GAR2) and animal (NCL) cells and its activity is controlled at both transcriptional and post transcriptional levels during cell growth and differentiation as well as in response to cellular stresses (Tajrishi et al., 2011; Berger et al., 2015). In contrast, plant genomes encode at least two NUC proteins. Here we described the functional characterization of NUC1 and NUC2 from Arabidopsis thaliana Col-0 ecotype.

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