Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
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Bastard, Paul | Gervais, Adrian | Taniguchi, Maki | Saare, Liisa | Särekannu, Karita | Le Voyer, Tom | Philippot, Quentin | Rosain, Jérémie | Bizien, Lucy | Asano, Takaki | Garcia-Prat, Marina | Parra-Martínez, Alba | Migaud, Mélanie | Tsumura, Miyuki | Conti, Francesca | Belot, Alexandre | Rivière, Jacques, G | Morio, Tomohiro | Tanaka, Junko | Javouhey, Etienne | Haerynck, Filomeen | Duvlis, Sotirija | Ozcelik, Tayfun | Keles, Sevgi | Tandjaoui-Lambiotte, Yacine | Escoda, Simon | Husain, Maya | Pan-Hammarström, Qiang | Hammarström, Lennart | Ahlijah, Gloria | Abi Haidar, Anthony | Soudee, Camille | Arseguel, Vincent | Abolhassani, Hassan | Sahanic, Sabina | Tancevski, Ivan | Nukui, Yoko | Hayakawa, Seiichi | Chrousos, George, P | Michos, Athanasios | Tatsi, Elizabeth-Barbara | Filippatos, Filippos | Rodriguez-Palmero, Agusti | Troya, Jesus | Tipu, Imran | Meyts, Isabelle | Roussel, Lucie | Ostrowski, Sisse Rye | Schidlowski, Laire | Prando, Carolina | Condino-Neto, Antonio | Cheikh, Nathalie | Bousfiha, Ahmed, A | El Bakkouri, Jalila | Aguilera-Albesa, Sergio | Alkhater, Suzan, A | Alkan, Gulsum | Castagnoli, Riccardo | Cyrus, Cyril | Elmas Bozdemir, Sefika | Emiroglu, Melike | Gulhan, Belgin | Erdeniz, Emine Hafize | Hatipoglu, Nevin | Bayhan, Gülsün Iclal | Jabandziev, Petr | Kanik Yuksek, Saliha | Karbuz, Adem | Tüter Öz, Şadiye Kübra | Marseglia, Gian Luigi | Metin Akcan, Ozge | Kılıç, Ahmet Osman | Ozkaya Parlakay, Aslinur | Papadaki, Maria | Slaba, Katerina | Sevketoglu, Esra | Valencia-Ramos, Juan | Yahşi, Aysun | Aguilera Guirao, Antonio | Álvarez Escudero, Julián | Antela López, Antonio | Barbeito Castiñeiras, Gema | Bello Paderne, Xabier | Ben García, Miriam | Carral García, María Victoria | Cebey López, Miriam | Coira Nieto, Amparo | Conde Pájaro, Mónica | Costa Alcalde, José Javier | Currás Tuala, María José | Dacosta Urbieta, Ana Isabel | Díaz Esteban, Blanca | Domínguez Santalla, María Jesús | Fernández Pérez, Cristina | Fernández Villaverde, Juan | Galbán Rodríguez, Cristóbal | García Allut, José Luis | García Vicente, Luisa | Giráldez Vázquez, Elena | Gómez Carballa, Alberto | Gómez Rial, José | González Barcala, Francisco Javier | Guerra Liñares, Beatriz | Leboráns Iglesias, Pilar | Lence Massa, Beatriz | Lendoiro Fuentes, Marta | López Franco, Montserrat | López Lago, Ana | Martinón-Torres, Federico | Salas, Antonio | Navarro de la Cruz, Daniel | Núñez Masid, Eloína | Ortolá Devesa, Juan Bautista | Pardo Seco, Jacobo | Pazo Núñez, María | Pérez del Molino Bernal, Marisa | Pérez Freixo, Hugo | Piñeiro Rodríguez, Lidia | Pischedda, Sara | Portela Romero, Manuel | Pose Reino, Antonio | Prada Hervella, Gloria María | Queiro Verdes, Teresa | Redondo Collazo, Lorenzo | Regueiro Casuso, Patricia | Rey García, Susana | Rey Vázquez, Sara | Riveiro Blanco, Vanessa | Rivero Calle, Irene | Rivero Velasco, Carmen | Rodríguez Núñez, Nuria | Rodríguez-Tenreiro Sánchez, Carmen | Saborido Paz, Eva | Sadiki Orayyou, José Miguel | Saito Villanueva, Carla | Serén Fernández, Sonia | Souto Sanmartín, Pablo | Taboada Muñiz, Manuel | Trastoy Pena, Rocío | Treviño Castellano, Mercedes | Valdés Cuadrado, Luis | Varela García, Pablo | Vilas Iglesias, María Soledad | Viz Lasheras, Sandra | Ferreiro-Iglesias, Rocio | Bastón-Rey, Iria | Calviño-Suárez, Cristina | Abel, Laurent | Aiuti, Alessandro | Al-Muhsen, Saleh | Al-Mulla, Fahd | Amara, Ali | Anderson, Mark, S | Andreakos, Evangelos | Arias, Andrés, A | Arkin, Lisa, M | Baris Feldman, Hagit | Biggs, Catherine, M | Bogunovic, Dusan | Bolze, Alexandre | Bondarenko, Anastasiia | Brodin, Petter | Bryceson, Yenan | Butte, Manish, J | Casanova, Jean-Laurent | Casari, Giorgio | Christodoulou, John | Cobat, Aurélie | Colobran, Roger | Constantinescu, Stefan, N | Cooper, Megan, A | Dalgard, Clifton, L | Desai, Murkesh | Drolet, Beth, A | Duval, Xavier | El Baghdadi, Jamila | Eloy, Philippine | Espinosa-Padilla, Sara | Fellay, Jacques | Flores, Carlos | Franco, José Luis | Froidure, Antoine | Gorochov, Guy | Gregersen, Peter, K | Grimbacher, Bodo | Hagin, David | Halwani, Rabih | Heath, James, R | Hsieh, Elena W.Y. | Husebye, Eystein | Imai, Kohsuke | Itan, Yuval | Jarvis, Erich, D | Jouanguy, Emmanuelle | Kaja, Elżbieta | Karamitros, Timokratis | Kisand, Kai | Ku, Cheng-Lung | Lau, Yu-Lung | Ling, Yun | Lucas, Carrie, L | Mansouri, Davood | Maródi, László | Mentré, France | Milner, Joshua, D | Mironska, Kristina | Mogensen, Trine, H | Ng, Lisa F.P. | Notarangelo, Luigi, D | Novelli, Antonio | Novelli, Giuseppe | O’Farrelly, Cliona | Okada, Satoshi | Okamoto, Keisuke | Pape, Jean, W | Perez de Diego, Rebeca | Perez-Tur, Jordi | Perlin, David, S | Pesole, Graziano | Planas, Anna, M | Pujol, Aurora | Puel, Anne | Quintana-Murci, Lluis | Ramaswamy, Sathishkumar | Renia, Laurent | Resnick, Igor | Rodríguez-Gallego, Carlos | Sancho-Shimizu, Vanessa | Sediva, Anna | Seppänen, Mikko R.J. | Shahrooei, Mohammed | Shcherbina, Anna | Slaby, Ondrej | Snow, Andrew, L | Soler-Palacín, Pere | Soumelis, Vassili | Spaan, András, N | Su, Helen, C | Tangye, Stuart, G | Abou Tayoun, Ahmad | Temel, Şehime Gülsün | Thorball, Christian | Tiberghien, Pierre | Trouillet-Assant, Sophie | Turvey, Stuart, E | Furkan Uddin, K.M. | Uddin, Mohammed, J | van de Beek, Diederik | Vinh, Donald, C | von Bernuth, Horst | Wauters, Joost | Zatz, Mayana | Zawadzki, Pawel | Zhang, Qian | Zhang, Shen-Ying | Peterson, Pärt | Lévy, Romain | Quartier, Pierre | Boisson, Bertrand | Béziat, Vivien | Borghesi, Alessandro | Pession, Andrea | Marr, Nico | Mentis, Alexios-Fotios A | Tillmann, Vallo | Neven, Bénédicte | Gómez-Carballa, Alberto | Gonzalez-Granado, Luis, I
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International audience.
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2.
