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Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation

Archive ouverte | Bornert, Alicia | CCSD

International audience. Platelets are produced by bone marrow megakaryocytes through cytoplasmic protrusions, named native proplatelets (nPPT), into blood vessels. Proplatelets also refer to pro...

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage

Archive ouverte | Pertuy, Fabien | CCSD

Background : Transgenic mice expressing cre recombinase under the control of the platelet factor4 (Pf4) promoter, in the context of a 100-kb bacterial artificial chromosome, have become a valuable tool with which to study genetic ...

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

Archive ouverte | Aguilar, Alicia | CCSD

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