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The RNA editing patterns are different in blood of euthymic and depressed bipolar patients. European Psychiatry

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Hayashi, Mirian A.F. | Cayzac, Christopher | Checa-Robles, Francisco Jesus | Salvetat, Nicolas | Weissmann, D. | Abraham, Jean-Daniel | Lozano, Camille

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International audience. Bipolar disorder (BD) is a severe mental disorder associated with functional impairment, high disability and premature mortality. Modifications of editing in mRNA of serotonin receptor subtype 2C (5-HTR2c) was reported by us in depressed suicide decedents. We have also identified a panel of RNA editing-based blood biomarkers for the diagnosis of BD, which also allowed to discriminate unipolar depression from BD with high sensivity and specificity.

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