MODOMICS: a database of RNA modifications and related information. 2023 update

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Cappannini, Andrea | Ray, Angana | Purta, Elżbieta | Mukherjee, Sunandan | Boccaletto, Pietro | Moafinejad, S, Naeim | Lechner, Antony | Barchet, Charles | Klaholz, Bruno, P. | Stefaniak, Filip | Bujnicki, Janusz, M

Edité par CCSD ; Oxford University Press -

International audience. The MOD OMICS database w as updated with recent data and no w includes ne w dat a t ypes related to RNA modifications. Changes to the database include an expanded modification catalog, encompassing both natural and synthetic residues identified in RNA structures. This addition aids in representing RNA sequences from the RCSB PDB database more effectively. To manage the increased number of modifications, adjustments to the nomenclature sy stem w ere made. Updates in the RNA sequences section include the addition of new sequences and the reintroduction of sequence alignments for tRNAs and rRNAs. The protein section was updated and connected to str uct ures from the RCSB PDB database and predictions b y AlphaFold. MOD OMICS no w includes a data annotation system, with 'Evidence' and 'Estimated Reliability' features, offering clarity on data support and accuracy. T his sy stem is open to all MODOMICS entries, enhancing the accuracy of RNA modification data representation.

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