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CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

Archive ouverte | Niborski, Leticia Laura | CCSD

International audience. Abstract Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint blockers are incompletel...

CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

Archive ouverte | Niborski, Leticia Laura | CCSD

International audience. Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint blockers are incompletely underst...

Epigenetic control of CD8+ T cell responsiveness to a-PD-1 by Suv39h1. Contrôle épigénétique de la réactivité des cellules T CD8+ à l'a-PD-1 par Suv39h1. Epigenetic control of CD8+ T cell responsiveness to a-PD-1 by Suv39h1: Contrôle épigénétique de la réactivité des cellules T CD8+ à l'a-PD-1 par Suv39h1

Archive ouverte | Niborski, Leticia Laura | CCSD

Tumor-infiltrating CD8+ T cells progressively lose functionality and fail to reject tumors. Theunderlying mechanism and re-programing induced by checkpoint blockers are incompletelyunderstood. We show that genetic ablation or phar...

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