RNA dynamics from experimental and computational approaches

Archive ouverte

Bussi, Giovanni | Bonomi, Massimiliano | Gkeka, Paraskevi | Sattler, Michael | Al-Hashimi, Hashim | Auffinger, Pascal | Duca, Maria | Foricher, Yann | Incarnato, Danny | Jones, Alisha | Kirmizialtin, Serdal | Krepl, Miroslav | Orozco, Modesto | Palermo, Giulia | Pasquali, Samuela | Salmon, Loïc | Schwalbe, Harald | Westhof, Eric | Zacharias, Martin

Edité par CCSD ; Elsevier (Cell Press) -

International audience. Understanding RNA dynamics from combining molecular modeling and experiment.

Computations provide a detailed characterization of RNA structure using physics and chemistrybased models, which might be inaccurate (left panel). Data obtained using bulk techniques such as NMR, cryo-EM, X-ray scattering, chemical probing, or melting experiments provide average and often sparse information (central panel). The combination of simulations and experiments enables accurate reconstruction of structural ensembles, both at the secondary and tertiary structure level, which are key for studying the interaction of RNAs with other molecules (right panel).

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion