NG2 expression in MLL rearranged acute myeloid leukaemia is restricted to monoblastic cases

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Mauvieux, L | Delabesse, Eric | Bourquelot, P | Radford-Weiss, I | Bennaceur, A | Flandrin, G | Valensi, F | Macintyre, E

Edité par CCSD ; Wiley -

International audience. Expression of NG2 has been reported in the majority of paediatric acute leukaemia (AL) cases with MLL rearrangement. We demonstrated 7.1 positivity in 2/3 paediatric and 4/11 adult MLL rearranged acute myeloid leukaemia (AML) but in 0/28 adult AML without MLL rearrangement, thus extending the 100% specificity to adult cases. Positivity correlated with stage of maturation arrest since it was found in 0/6 immature AML but in 6/8 monoblastic cases. These data demonstrate that, if NG2 expression in AL is the (in)direct result of MLL rearrangement, such activation is restricted to a monoblastic population in AML. They also have practical implications for NG2 diagnostic screening strategies.

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