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Monogenic lupus: Dissecting heterogeneity

Archive ouverte | Omarjee, Ommar | CCSD

Systemic lupus erythematosus (SLE) is a severe lifelong multisystem autoimmune disease characterized by the presence of autoantibodies targeting nuclear autoantigens, increased production of type I interferon and B cell abnormalit...

Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts

Archive ouverte | Belot, Alexandre | CCSD

International audience. BackgroundSystemic lupus erythematosus (SLE) is a rare immunological disorder and genetic factors are considered important in its causation. Monogenic lupus has been associated with around 30...

Early-onset autoimmunity associated with SOCS1 haploinsufficiency

Archive ouverte | Hadjadj, Jérôme | CCSD

International audience. Abstract Autoimmunity can occur when a checkpoint of self-tolerance fails. The study of familial autoimmune diseases can reveal pathophysiological mechanisms involved in more common autoimmun...

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