Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies

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Jentzer, Alexandre | El-Bechir, Jérémie | Taieb, Guillaume | Devaux, Jérôme J

Edité par CCSD -

Background and objectives: Dihydrolipoamide S-Acetyltransferase (DLAT), the E2 component of the mitochondrial pyruvate dehydrogenase complex (PDC-E2), has recently been suggested to be a biomarker of chronic inflammatory demyelinating polyneuropathy (CIDP). It was particularly associated with sensory variants of CIDP. Anti-mitochondrial antibodies are important for the diagnosis of primary biliary cholangitis, but insofar, only two studies have reported an association with CIDP. Here, we aimed to validate these observations in a cohort of French patients with immune-mediated neuropathy.Methods: The positivity against PDC-E2/DLAT was examined using enzyme-linked immunosorbent assay, and confirmed using commercially available immuno-DOT and by indirect immunofluorescence on stomach, kidney, and liver sections.Results: None of the 20 healthy controls, 31 patients with Guillain-Barré syndrome, 102 patients with CIDP (including 24 patients with sensory CIDP), 26 patients with monoclonal gammopathy, 23 patients with Charcot-Marie-Tooth disease, or 20 patients with autoimmune nodopathy showed IgG against PDC-E2/DLAT.Discussion: PDC-E2/DLAT is accurately a target antigen in immune-mediated neuropathies.

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