Sheltering of deleterious mutations explains the stepwise extension of recombination suppression on sex chromosomes and other supergenes: Details of the questions addressed, main arguments and breadth of the parameter values explored in simulations in Jay et al (2022)

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Jay, Paul | Tezenas Du Montcel, Emilie | Véber, Amandine | Giraud, Tatiana

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In the manuscript entitled “Do deleterious mutations promote the evolution of recombination suppression between X and Y chromosomes?” [1], the authors question the methodology and findings presented in our study on the role of deleterious mutations in the formation of sex chromosomes [2]. The present document is intended to answer the expressed concerns by explaining in more details why, in our Figure 3C [2], our approach was valid in setting aside:(1) simulations in which the inversion does not survive the first 20 generations;(2) simulations corresponding to the case « s=0 » (i.e., all mutations are neutral).

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