Skin Barrier and Microbiome
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International audience. The skin is the outermost barrier of the organism that ensures protection from external harm. Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ that can sense danger signals and mount perfectly adapted defense measures in response to invading pathogens. This article describes the different levels of the cutaneous barrier, and how it is an interconnected network of cells with microbiome - that allows balanced defense measures to protect the body and maintain barrier integrity. Under stress, aggressions of the skin, the symbiotic relationship changes into a dysbiotic one resulting in skin inflammatory disorders. Thus, the skin microbiota may have either positive or negative influence on the immune system. This article also shows the impact of dysbiosis on the well-coordinated immune responses in host defense.
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