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Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: the 2022 update of the recommendations by ERIC, the European Research Initiative on CLL

Archive ouverte | Agathangelidis, Andreas | CCSD

International audience. The somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene is a critical biomarker for assessing the prognosis of patients with chronic lymphocytic leu...

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Archive ouverte | Agathangelidis, Andreas | CCSD

International audience. Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients with (quasi)identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain major...

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Archive ouverte | Baliakas, Panagiotis | CCSD

International audience. An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3...

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