Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly

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Singh, Abhishek | Winnerdy, Fernaldo, Richtia | Avila, Constanza, Avendaño | Nogues, Claude | Phan, Anh, Tuân | Heddi, Brahim

Edité par CCSD ; American Chemical Society -

International audience. G-quadruplexes are noncanonical structures of nucleic acids formed mainly by G-rich sequences and play crucial roles in important cellular processes. They are also increasingly used in nanotechnology for their valuable properties. Various unexpected structures of G-quadruplexes have been solved recently, including a stable G-quadruplex lacking one guanine in the G-tetrad core, harboring a vacant site. In this study, we demonstrate the interlocking of two intramolecular G-quadruplexes: one containing a vacant site (4n -1) and the other with an unbound guanine (4n + 1). These G-quadruplexes interact through a G-triad-G connection with unprecedented 5′-3′ stacking. Using these interconnection properties, we have identified a sequence capable of self-assembling into G-wires in K + solutions with potential nanotechnological applications.

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