Chromosome-Encoded Class D β-Lactamase OXA-23 in Proteus mirabilis

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Bonnet, R. | Marchandin, H. | Chanal, C. | Sirot, D. | Labia, R. | de Champs, C. | Jumas-Bilak, Estelle | Sirot, J.

Edité par CCSD ; American Society for Microbiology -

International audience. ABSTRACT Ten nonrepetitive Proteus mirabilis isolates, which were collected over 4 years (1996 to 1999) at the teaching hospital of Clermont-Ferrand, France, produced class D carbapenemase OXA-23. MICs of imipenem were 0.25 to 0.5 μg/ml for these clinical isolates. Molecular typing revealed that the 10 P. mirabilis isolates originated from the same clonal strain. Hybridization of I- Ceu I-generated chromosome fragments with a bla OXA-23 probe showed that the gene was chromosome encoded in the P. mirabilis strain.

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