Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study
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Semenchuk, Julie | Naito, Yumi | Charman, Susan, C | Carr, Siobhán, B | Cheng, Stephanie, Y | Marshall, Bruce, C | Faro, Albert | Elbert, Alexander | Gutierrez, Hector, H | Goss, Christopher, H | Karadag, Bulent | Burgel, Pierre-Régis | Colombo, Carla | Salvatore, Marco | Padoan, Rita | Daneau, Géraldine | Harutyunyan, Satenik | Kashirskaya, Nataliya | Kirwan, Laura | Middleton, Peter, G | Ruseckaite, Rasa | de Monestrol, Isabelle | Naehrlich, Lutz | Mondejar-Lopez, Pedro | Jung, Andreas | van Rens, Jacqui | Bakkeheim, Egil | Orenti, Annalisa | Zomer-van Ommen, Domenique | da Silva-Filho, Luiz, Vicente Rf | Fernandes, Flavia, Fonseca | Zampoli, Marco | Stephenson, Anne, L | Kasmi, Irena | Drali, Ouardia | Burghart, Sabine | Lakatos-Krepcik, Andrea | Eder, Johannes | Jaksch, Peter | Kainz, Katharina | Kallinger, Margit | Leitner, Alexander | Mozdzen, Marta | Pfleger, Andreas | Renner, Sabine | Stadlinger, Martin | Thir, Christina | Nuriyev, Emil | Boboli, Hedwige | de Wachter, Elke | 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Chiron, Raphael | Duet, Emmanuelle, Coirier | Cosson, Laure | Dalphin, Marie-Laure | Boucher, Isabelle, Danner | de Miranda, Sandra | Deneuville, Eric | Dubus, Jean-Christophe | Durieu, Isabelle | Epaud, Ralph | Gerardin, Michèle | Grenet, Dominique | Houdouin, Véronique | Huet, Frédéric | Reem, Kanaan | Kessler, Romain | Languepin, Jeanne | Laurans, Muriel | Leroy, Sylvie | Llerena, Cathie | Macey, Julie | Mankikian, Julie | Marguet, Christophe | Martin, Clémence | Mely, Laurent | Mittaine, Marie | Murris-Espin, Marlène | Perisson, Caroline | Prevotat, Anne | Ramel, Sophie | Rames, Cinthia | Reix, Philippe | Revillon, Marine | Reynaud-Gaubert, Martine | Richaud-Thiriez, Bénédicte | Rittie, Jean-Luc | Scalbert-Dujardin, Manuëla | Sermet-Gaudelus, Isabelle | Storni, Véronique | Tatopoulos, Aurélie | Thouvenin, Guillaume | Troussier, Françoise | Weiss, Laurence | Wizla, Nathalie | Behl, Eva-Susanne | Brinkmann, Folke | Claßen, Martin | Graepler-Mainka, Ute | Griese, Matthias | Grübl, Armin | Hammermann, Jutta | Hebestreit, Helge | Heinzmann, Andrea | Herz, Alexander | Kiefer, Alexander | Kinder, Birte | Köster, Holger | Kuhnert, Stefan | Mainz, Jochen | Mayer, Angelika | Naehrig, Susanne | Niehues, Tim | Nüßlein, Thomas | Poplawska, Krystyna | Ringshausen, Felix | Rose, Markus | Rosenecker, Josef | Ruppel, Renate | Scharschinger, Anette | Schropp, Christian | Schwarz, Carsten | Smaczny, Christina | Sommerburg, Olaf | Sutharsan, Sivagurunathan | Stolz, Simone | Thomas, Wolfgang | Wege, Sabine | Welzenbach, Britta | Wollschläger, Bettina | Diamantea, Filia | Hatziagorou, Elpis | Manika, Katerina | Cox, Des | Elnazir, Basil | Fletcher, Godfrey | Gunaratnam, Cedric | Mckone, Edward, F | Plant, Barry, J | Cohen-Cymberknoh, Malena | Gur, Michal | Livnat, Galit | Mei-Zahav, Meir | Amato, Annalisa | Ferrari, Gianluca | Badolato, Raffaele | Poli, Piercarlo | Battistini, Fiorella | Donati, Valentina | Bignamini, Elisabetta | Folino, Anna | Carnovale, Vincenzo | Castellani, 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Geert-Jan | de Winter, Karin | Danevska, Ivana, Arnaudova | Maretti, Tatjana, Jakovska | Fustik, Stojka | Dziecichowicz-Latała, Daria | Wojsyk-Banaszak, Irena | Wozniacki, Lukasz | Amorim, Adelina | Santos, Ana, Sofia Araújo | Castanhinha, Susana | Gamboa, Fernanda | Silva, Teresa, Reis | Gonçalves, Fabienne | Pereira, Luísa | Ciuca, Ioana | Silva, Sónia | Csilla-Enikö, Szabo | Stan, Iustina | Amelina, Elena | Boitсova, Evgeniya | Chernyavskaya, Anastasia | Gorinova, Yuliya | Krasovskiy, Stanislav | Mukhina, Maria | Sherman, Victoria | Simonova, Olga | Kondratyeva, Elena | Bérešová, Eva | Bližnáková, Nina | Kayserová, Hana | Salobir, Barbara | Šelb, Julij | Krivec, Uroš | Fernandez, Antonio, José Aguilar | Fernàndez, Antonio, Alvarez | García, Félix, Baranda | Aparicio, Marina, Blanco | Corullón, Silvia, Castillo | Cortell-Aznar, Isidoro | Pérez, Inés | Colomer, Jordi, Costa I | Roig, María, Cols | Pecellín, Isabel, Delgado | Cáceres, Layla, Diab | Paredes, Carmen, Luna | Gartner, Silvia | Martínez, José, Ramón Gutiérrez | Labarga, Inés, Herrero | Girón-Moreno, Rosa, Maria | Nogueira, Esperanza, Jiménez | Ferreiro, Adelaida, Lamas | Neyra, Alejandro, López | Castro, Enrique, Blitz | Galarraga, Laura, Moreno | de Vincente, Carlos, Martin | Navarro, Silvia, Merlos | Nieto-Royo, Rosa | Fuster, Casilda, Olveira | Pastor, Maria, Dolores | Pérez-Ruiz, Estela | Prados-Sánchez, Concepción | Cancelo, Isabel, Ramos | de Valbuena, Marta, Ruiz | Asensi, José, R Villa | Santiago, Veronica, Sanz | García, Patricia, Fernández | Tawfeeq, Reem, Mustafa | Banki, Adrienn | Gilljam, Marita | Krantz, Christina | Lindberg, Ulrika | Lindblad, Anders | Clarenbach, Christian | Steinack, Carolin | Hage, René | Schuurmans, Macé | Fischer, Reta | Kusche, Rachel | Rochat, Isabelle | Walter, Anna-Lena | Kamalaporn, Harutai | Hamouda, Samia | Tural, Dilber, Ademhan | Ozcelik, Ugur | Asfuroğlu, Pelin | Eyüboğlu, Tuğba, Şişmanlar | Aslan, Ayse, Tana | Bingöl, Ayşen | Çobanoğlu, Nazan | Ozcan, Gizem | Dogru, Deniz | Gökdemir, Yasemin | Köse, Mehmet | Pekcan, Sevgi | Cosgriff, Rebecca
Edité par
CCSD ; Elsevier -
International audience.
Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV 1 ) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV 1 and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.Results: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV 1 pre-and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre-and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.Conclusions: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.
