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Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection

Archive ouverte | Wolski, David | CCSD

International audience. Distinct molecular pathways govern the differentiation of CD8+ effector T cells into memory or exhausted T cells during acute and chronic viral infection, but these are not well studied in hu...

MICA Variant Promotes Allosensitization after Kidney Transplantation

Archive ouverte | Tonnerre, Pierre | CCSD

International audience. MHC class I-related chain A (MICA) antigens are surface glycoproteins strongly implicated in innate immunity , and the MICA gene is highly polymorphic. Clinical observations suggest a role fo...

HLA-E-Restricted Cross-Recognition of Allogeneic Endothelial Cells by CMV-Associated CD8 T Cells: A Potential Risk Factor following Transplantation

Archive ouverte | Allard, Mathilde | CCSD

International audience. Although association between CMV infection and allograft rejection is well admitted, the precise mechanisms involved remain uncertain. Here, we report the characterization of an alloreactive ...

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