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Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice

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Wong, Ting | Horspool, Alexander | Russ, Brynnan | Ye, Chengjin | Lee, Katherine | Winters, Michael | Bevere, Justin | Miller, Olivia | Rader, Nathaniel | Cooper, Melissa | Kieffer, Theodore | Sourimant, Julien | Greninger, Alexander | Plemper, Richard | Denvir, James | Cyphert, Holly | Barbier, Mariette | Torrelles, Jordi | Martinez, Ivan | Martinez-Sobrido, Luis | Damron, F. Heath

Edité par CCSD ; American Society for Microbiology -

International audience. Emerging SARS-CoV-2 VoC are posing new problems regarding vaccine and monoclonal antibody efficacy. To better understand immune evasion tactics of the VoC, we utilized passive immunization to study the effect of early-pandemic SARS-CoV-2 HCP against, Alpha, Beta, and Delta VoC.

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