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Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids
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- An introduction to Ascaris physiology and pharmacology – highlighting opportunities for anthelmintic discovery- Ascaris physiology, drug action, and the gut-drug axis- Host-environmental interactions of Ascaris- The current scope and future perspectives of Caenorhabditis elegans as a tool for ascarid research- Genomics – genomic/transcriptomic analyses of ascarids- Current challenges in vaccine research against ascarids and future perspectives- Discussions on important future topics in research on ascarids. International audience. The ascarids are a large group of parasitic nematodes that infect a wide range of animal species. In humans, they cause neglected diseases of poverty; many animal parasites also cause zoonotic infections in people. Control measures include hygiene and anthelmintic treatments, but they are not always appropriate or effective and this creates a continuing need to search for better ways to reduce the human, welfare and economic costs of these infections. To this end, Le Studium Institute of Advanced Studies organized a two-day conference to identify major gaps in our understanding of ascarid parasites with a view to setting research priorities that would allow for improved control. The participants identified several key areas for future focus, comprising of advances in genomic analysis and the use of model organisms, especially Caenorhabditis elegans, a more thorough appreciation of the complexity of host-parasite (and parasite-parasite) communications, a search for novel anthelmintic drugs and the development of effective vaccines. The participants agreed to try and maintain informal links in the future that could form the basis for collaborative projects, and to co-operate to organize future meetings and workshops to promote ascarid research.
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