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Carney complex predisposes to breast cancer: prospective study of 50 women.

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Vaduva, Patricia | Violon, Florian | Jouinot, Anne | Bouys, Lucas | Stephanie, Espiard | Bonnet-Serrano, Fidéline | North, Marie Odile | Cardot-Bauters, Catherine | Raverot, Gerald | Hieronimus, Sylvie | Lefebvre, Hervé | Nunes, Marie-Laure | Tabarin, Antoine | Groussin, Lionel | Assié, Guillaume | Sibony, Mathilde | Vantyghem, Marie-Christine | Pasmant, Eric | Bertherat, Jérôme

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International audience. Carney complex (CNC) is a rare genetic syndrome, mostly due to germline loss-of-function pathogenic variants in PRKAR1A. Carney complex includes pigmented skin lesions, cardiac myxomas, primary pigmented nodular adrenocortical dysplasia, and various breast benign tumors.

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