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GABA signaling stimulates α-cell-mediated β-like cell neogenesis

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Napolitano, Tiziana | Avolio, Fabio | Vieira, Andhira | Ben-Othman, Nouha | Courtney, Monica | Gjernes, Elisabet | Hadzic, Biljana | Druelle, Noémie | Navarro Sanz, Sergi | Silvano, Serena | Mansouri, Ahmed | Collombat, Patrick

Edité par CCSD ; Taylor & Francis Open -

International audience. Diabetes is a chronic and progressing disease, the number of patients increasing exponentially, especially in industrialized countries. Regenerating lost insulin-producing cells would represent a promising therapeutic alternative for most diabetic patients. To this end, using the mouse as a model, we reported that GABA, a food supplement, could induce insulin-producing beta-like cell neogenesis offering an attractive and innovative approach for diabetes therapeutics.

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