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Sleep Disordered Breathing association with cardiovascular disease in the French general population
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Edité par CCSD ; European Respiratory Society -
International audience. Background: Sleep Disordered Breathing (SDB) is highly prevalent and associated with cardiovascular disease (CVD). The aim of this study was to assess its association with CVD in a large French population-based sample.Methods: Data came from participants of the French population-based CONSTANCES cohort, included between 2012 and 2016 and screened for SDB in 2017 using the Berlin Questionnaire (BQ). CVD occurrence was defined by self-declared myocardial infarction or stroke between 2013 and 2017 in yearly questionnaires. Exposure variables were SDB diagnosis on the basis on BQ and its related symptoms. Odds Ratios (OR) were adjusted for age, sex, smoking, dyslipidemia, diabetes, hypertension and body mass index (except for SDB since BQ considers these variables).Results: Among 54 228 participants, SDB prevalence was 16.1%. Over four years of follow-up, CVD occurred in 2.23% of SDB participants vs 0.72% in non SDB (OR=1.72, 95% CI [1.41-2.09]). CVD occurrence did not increase significantly with snoring (OR=0.95, 95% CI [0.78;1.17]), but with apnea (OR=1.34, 95% CI [1.05;1.71]) and with sleepiness (OR=1.42, 95% CI [1.18-1.72] when it occurred after-sleep and OR=1.62, 95% CI [1.33-1.97] during waking time). These associations remained non-significant for snoring regardless of its frequency or noise, were significant for sleepiness as soon as it happened at least once a week and increased with its frequency whenever fatigue occurred (p for trend<0.001).Conclusion: These results confirm that SDB is associated with a higher occurrence of CVD particularly in sleepy and apneic subjects. SDB screening should be relevant to identify people who would benefit from preventive measures.
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