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Anal and oropharyngeal HPV distribution in HIV‐negative multipartner MSM using self‐sampling kits for HIV and sexually transmitted infection screening
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Edité par CCSD ; Wiley-Blackwell -
International audience. Abstract Men who have sex with men (MSM) are at high risk of sexually transmitted infections, among which HPV infections are particularly prominent. We took advantage of the MémoDépistages study to evaluate HPV distribution at anal and oropharyngeal sites in HIV‐negative multipartner MSM. HPV DNA was detected in 82% ( n = 344) of anal and 11% ( n = 45) of oropharyngeal self‐collected samples taken from 421 participants. Multiple HPV types were detected in 70% of anal samples, and single HPV types in 91% of oropharyngeal samples. HPV16 was the most frequent type detected in the anus, followed by HPV6, HPV51, and HPV52. HPV6, HPV16, and HPV11 were the most prevalent types in the oropharynx. HPV targeted by the nonavalent vaccine was detected in 71% and 50% of HPV‐positive anal and oropharyngeal samples, respectively. The main risk factor associated with HPV detection was frequenting gay meeting places, living in large cities, and having an anal Chlamydia trachomatis / Neisseria gonorrhoeae infection. In this cohort of highly sexually active MSM, HPV detection was highly frequent and rendered them at high risk of precancerous and cancerous lesions. Universal vaccination against HPV before sexual debut is an important public health strategy to prevent HPV‐associated cancers in this highly vulnerable population of HIV‐negative MSM.
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