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Generation of human induced pluripotent stem cell lines from two patients affected by catecholamine-induced QT prolongation (CIQTP)

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Cimarosti, Bastien | Canac, Robin | Girardeau, Aurore | Arnaud, Marine | Francheteau, Quentin | Probst, Vincent | Lemarchand, Patricia | Redon, Richard | Gourraud, Jean-Baptiste | Gaborit, Nathalie | Lamirault, Guillaume

Edité par CCSD ; Elsevier -

International audience. Catecholamine-induced QT prolongation (CIQTP) is an inherited cardiac disease characterized by a normal baseline ECG and a risk of sudden cardiac death by ventricular arrhythmia due to a QT prolongation that only appears during catecholergic stimulation, especially mental stress. Induced pluripotent stem cells (hiPSCs) were generated from peripheral blood mononuclear cells collected from two CIQTP-affected patients from two different families. These two hiPSC lines are a valuable model to study biological alterations due to CIQTP.

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