Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study
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Simoes, Margarida Pires | Hodcroft, Emma | Simmonds, Peter | Albert, Jan | Alidjinou, Enagon | Ambert-Balay, Katia | Andrés, Cristina | Antón, Andrés | Auvray, Christelle | Bailly, Jean-Luc | Baldanti, Fausto | Bastings, Capser | Beard, Stuart | Pereira, Carla Berengua | Berginc, Natasa | Bloemen, Mandy | Blomqvist, Soile | Bosma, Froukje | Böttcher, Sindy | Bubba, Laura | Buderus, Stafan | Cabrerizo, Maria | Calvo, Christina | Celma, Christina | Ceriotti, Ferruccio | Clark, Gemma | Costa, Inës | Coste-Burel, Marianne | Couderé, Karen | Cremer, Jeroen | del Cuerpo Casas, Margarita | Daehne, Theo | de Beer, Jessica | de Ceano-Vivas, Maria | de Gascun, Cillian | de Rougemont, Alexis | Dean, Johnathan | Dembinski, Jennifer | Diedrich, Sabine | Diez-Domingo, Javier | Dillner, Lena | Dorenberg, Dagny | Ducancelle, Alexandra | Dudman, Susanne | Dyrdak, Robert | Eis-Huebinger, Anna-Maria | Falces-Romero, Iker | Farkas, Agnes | Feeney, Susan | Fernandez-Garcia, Maria | Flipse, Jacky | Franck, Kristina | Galli, Cristina | Garrigue, Isabelle | Geeraedts, Felix | Georgieva, Irina | Giardina, Federica | Guiomar, Raquel | Hauzenberger, Elenor | Heikens, Esther | Henquell, Cécille | Hober, Didier | Hönemann, Amrio | Howson-Wells, Hannah | Hruškar, Željka | Ikonen, Niina | Imbert, Berthemarie | Jansz, Arjan | Jeannoël, Marion | Jiřincová, Helena | Josset, Laurence | Keeren, Kathrin | Kramer-Lindhout, Naomie | Krokstad, Sidsel | Lazrek, Mouna | Le Guillou-Guillemette, Hélène | Lefeuvre, Caroline | Lind, Andreas | Lunar, Maja | Maier, Melanie | Marque-Juillet, Stéphanie | Mcclure, C Patrick | Mckenna, James | Meijer, Adam | Menasalvas Ruiz, Ana | Mengual-Chuliá, Beatriz | Midgley, Sofie | Mirand, Audrey | Molenkamp, Richard | Montes, Milagrosa | Moreno-Docón, Antonio | Morley, Ursula | Murk, Jean-Luc | Navascués-Ortega, Ana | Nijhuis, Roel | Nikolaeva-Glomb, Lubomira | Nordbø, Svein | Numanovic, Sanela | Oggioni, Massimo | Oñate Vergara, Eider | Pacaud, Jordi | Pacreau, Marie | Panning, Marcus | Pariani, Elena | Pekova, Lili | Pellegrinelli, Laura | Petrovec, Miroslav | Pietsch, Corinna | Pilorge, Léa | Piñeiro, Luis | Piralla, Antonio | Poljak, Mario | Prochazka, Birgit | Rabella, Nuria | Rahamat-Langendoen, Janette | Rainetova, Petra | Reynders, Marijke | Riezebos-Brilman, Annelies | Roorda, Lieuwe | Savolainen-Kopra, Carita | Schuffenecker, Isabelle | Smeets, Leo | Stoyanova, Ayse | Stefic, Karl | Swanink, Caroline | Tabain, Irena | Tjhie, Jeroen | Thouault, Luc | Tumiotto, Camille | Uceda Renteria, Sara | Uršič, Tina | Vallet, Sophie | van Ranst, Marc | van Wunnik, Peter | Verweij, Jaco | Vila, Jorgina | Wintermans, Bas | Wollants, Elke | Wolthers, Katja | Xavier López-Labrado, F | Fischer, Thea Kolsen | Harvala, Heli | Benschop, Kimberley
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CCSD ; Oxford University Press -
International audience.
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages.
