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The colibactin-producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance

Archive ouverte | de Oliveira Alves, Nilmara | CCSD

International audience. Intratumoral bacteria flexibly contribute to cellular and molecular tumor heterogeneity for supporting cancer recurrence through poorly understood mechanisms. Using spatial metabolomic profil...

Spatial metabolomics reveals a reprogramming of lipid metabolism by bacterial colibactin supporting immunosuppressive microenvironment in right-sided colon cancer

Archive ouverte | de Oliveira Alves, Nilmara | CCSD

International audience. Introduction: Intratumoral bacteria contribute to tumor heterogeneity through poorly understood mechanisms. It has been established thatpatients with right-sided colon cancer (RCC) exhibit a ...

Spatially-resolved metabolomic identifies a reprogramming of lipid metabolism and immune surveillance that are caused by colibactin-producing E. coli infection.

Archive ouverte | de Oliveira Alves, Nilmara | CCSD

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