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M‐CSF‐mediated macrophage development is dominantly inhibited by NOD2 signaling for replenishment of immunogenic dendritic cells

Archive ouverte | Chauvin, Camille | CCSD

International audience. Despite recent advances, it remains unclear whether monocyte‐derived dendritic cells (moDCs) represent alternative context‐dependent fate in the gut. We found here that Nod2‐ dependent sensin...

NOD2 in monocytes negatively regulates macrophage development through TNFalpha

Archive ouverte | Chauvin, Camille | CCSD

International audience. Objective It is believed that intestinal recruitment of monocytes from Crohn’s Disease (CD) patients who carry NOD2 risk alleles may repeatedly give rise to recruitment of pathogenic macropha...

Loss of NOD2 in macrophages improves colitis and tumorigenesis in a lysozyme-dependent manner

Archive ouverte | Chauvin, Camille | CCSD

International audience. Background Crohn’s disease (CD) is a complex and poorly understood myeloid-mediated disorder. Genetic variants with loss of function in the NOD2 gene confer an increased susceptibility to ile...

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