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Rare ZMPSTE24 variants increase risk of hypertriglyceridemia and metabolic syndrome

Archive ouverte | Le Collen, Lauriane | CCSD

International audience. Abstract Objective The global increase in the prevalence of metabolic syndrome represents a significant public health concern. Rare biallelic pathogenic variants in ZMPSTE24 have been identif...

Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use

Archive ouverte | Le Collen, Lauriane | CCSD

International audience. Purpose: Recessive deficiency of proopiomelanocortin (POMC) causes childhood-onset severe obesity. Cases can now benefit from the melanocortin 4 receptor agonist setmelanotide. Furthermore, a...

Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function

Archive ouverte | Meulebrouck, Sarah | CCSD

International audience. Functional genetics has identified drug targets for metabolic disorders. Opioid use impacts metabolic homeostasis, although mechanisms remain elusive. Here, we explore the OPRD1 gene (encodin...

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