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Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness

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Luppi, Andrea, I | Cabral, Joana | Cofre, Rodrigo | Mediano, Pedro A.M. | Rosas, Fernando, E | Qureshi, Abid, Y | Kuceyeski, Amy | Tagliazucchi, Enzo | Raimondo, Federico | Deco, Gustavo | Shine, James, M | Kringelbach, Morten, L | Orio, Patricio | Ching, Shinung | Sanz Perl, Yonatan | Diringer, Michael, N | Stevens, Robert, D | Sitt, Jacobo Diego

Edité par CCSD ; Elsevier -

International audience. Highlights • Overview of the wide range of modelling strategies for disorders of consciousness. • Descriptive and generative statistical models, biophysical computational models. • Gap analysis of challenges to DOC modelling and recommendations to overcome them. • Towards personalised models for diagnosis and treatment of DOC with multimodal data. • “Phase Zero” in silico clinical trials of potential treatments via brain modelling.

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