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Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System

Archive ouverte | Schumacher, Michael | CCSD

International audience. The utility and safety of postmenopausal hormone replacement therapy has recently been put into question by large clinical trials. Their outcome has been extensively commented upon, but discu...

Neuroprotection by steroids after neurotrauma in organotypic spinal cord cultures: A key role for progesterone receptors and steroidal modulators of GABAA receptors

Archive ouverte | Labombarda, Florencia | CCSD

International audience. Progesterone is neuroprotective after spinal cord injury, however its mechanism of action remains unexplored. Here we used organotypic spinal cord slice cultures from 3 weeks-old mice to eval...

Progesterone Synthesis in the Nervous System: Implications for Myelination and Myelin Repair

Archive ouverte | Schumacher, Michael | CCSD

International audience. Progesterone is well known as a female reproductive hormone and in particular for its role in uterine receptivity, implantation, and the maintenance of pregnancy. However, neuroendocrine rese...

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