Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum

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Meffre, Delphine | Shackleford, Ghjuvan’ghjacumu | Hichor, Mehdi | Gorgievski, Victor | Tzavara, Eleni | Trousson, Amalia | Ghoumari, Abdel, M | Deboux, Cyrille | Nait Oumesmar, Brahim | Liere, Philippe | Schumacher, Michael | Baulieu, Etienne-Emile | Charbonnier, Frédéric | Grenier, Julien | Massaad, Charbel

Edité par CCSD ; National Academy of Sciences -

International audience. Significance Liver X receptors (LXRs) α and β are the two major receptors of oxysterols, oxygenated derivatives of cholesterol. They control the homeostasis of cholesterol, an important lipid constituent of myelin sheaths. In the central nervous system, these insulating structures are generated by oligodendrocytes and are stabilized by myelin proteins. Here, we provide evidence of a new role of LXRs in the myelin physiology of the cerebellum. Mice invalidated for both LXRs exhibit alteration in motor coordination and spatial learning linked with myelination deficits. We demonstrated that LXRs intervene both in oligodendroglial cell maturation and in the transcriptional control of myelin gene expression during (re)myelination processes.

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