HLA in isolated REM sleep behavior disorder and Lewy body dementia
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Yu, Eric | Krohn, Lynne | Ruskey, Jennifer, A | Asayesh, Farnaz | Spiegelman, Dan | Shah, Zalak | Chia, Ruth | Arnulf, Isabelle | Hu, Michele, T M | Montplaisir, Jacques, Y | Gagnon, Jean‐françois | Desautels, Alex | Dauvilliers, Yves | Gigli, Gian Luigi | Valente, Mariarosaria | Janes, Francesco | Bernardini, Andrea | Högl, Birgit | Stefani, Ambra | Ibrahim, Abubaker | Heidbreder, Anna | Sonka, Karel | Dusek, Petr | Kemlink, David | Oertel, Wolfgang | Janzen, Annette | Plazzi, Giuseppe | Antelmi, Elena | Figorilli, Michela | Puligheddu, Monica | Mollenhauer, Brit | Trenkwalder, Claudia | Sixel‐döring, Friederike | Cochen de Cock, Valérie | Ferini‐strambi, Luigi | Dijkstra, Femke | Viaene, Mineke | Abril, Beatriz | Boeve, Bradley, F | Rouleau, Guy, A | Postuma, Ronald, B | Scholz, Sonja, W | Gan‐or, Ziv | Sixel-Döring, Friederike | Abramzon, Yevgeniya | Ahmed, Sarah | Alba, Camille | Albert, Marilyn S. | Bacikova, Dagmar | Barrett, Matthew J. | Beach, Thomas G. | Bennett, David A. | Besser, Lilah M. | Bigio, Eileen H. | Boeve, Bradley F. | Bohannan, Ryan C. | Caraway, Chad A. | Palma, Jose-Alberto | Dalgard, Clifton L. | Dickson, Dennis | Ding, Jinhui | Faber, Kelley | Ferman, Tanis | Ferrucci, Luigi | Flanagan, Margaret E. | Foroud, Tatiana M. | Ghetti, Bernardino | Gibbs, J. Raphael | Goate, Alison | Goldstein, David | Graff-Radford, Neill R. | Hu, Heng-Chen | Hupalo, Daniel | Kaiser, Scott M. | Kaufmann, Horacio | Kim, Ronald C. | Klein, Gregory | Kukull, Walter | Kuzma, Amanda | Leverenz, James | Lopez, Grisel | Mao, Qinwen | Martinez-Mcgrath, Elisa | Masliah, Eliezer | Monuki, Ed | Newell, Kathy L. | Norcliffe-Kaufmann, Lucy | Perkins, Matthew | Pletnikova, Olga | Renton, Alan E. | Resnick, Susan M. | Ross, Owen A. | Sabir, Marya S. | Scherzer, Clemens R. | Scholz, Sonja W. | Serrano, Geidy | Shakkotai, Vikram | Sidransky, Ellen | Singleton, Andrew B. | Tanaka, Toshiko | Tayebi, Nahid | Traynor, Bryan J. | Troncoso, Juan C. | Viollet, Coralie | Walton, Ronald L. | Woltjer, Randy | Wszolek, Zbigniew K. | Black, Sandra E. | Gan-Or, Ziv | Keith, Julia | Masellis, Mario | Rogaeva, Ekaterina | Aarsland, Dag | Al-Sarraj, Safa | Attems, Johannes | Ferrari, Raffaele | Gentleman, Steve | Hardy, John A. | Hodges, Angela K. | Love, Seth | Mckeith, Ian | Morris, Christopher M. | Morris, Huw R. | Palmer, Laura | Pickering-Brown, Stuart | Reynolds, Regina H. | Ryten, Mina | Thomas, Alan J. | Tilley, Bension S. | Troakes, Claire | Brett, Francesca | Brice, Alexis | Duyckaerts, Charles | Lesage, Suzanne | Brunetti, Maura | Calvo, Andrea | Canosa, Antonio | Chiò, Adriano | Floris, Gianluca | Logroscino, Giancarlo | Zecca, Chiara | Clarimon, Jordi | Diez-Fairen, Monica | Fortea, Juan | González-Aramburu, Isabel | Infante, Jon | Lage, Carmen | Lleó, Alberto | Pastor, Pau | Porcel-Molina, Laura | Rodríguez-Rodríguez, Eloy | Sanchez-Juan, Pascual | Krüger, Rejko | May, Patrick | Xiromerisiou, Georgia
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CCSD ; Wiley -
International audience.
Abstract Synucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen ( HLA ) locus plays a role in iRBD and LBD. In iRBD, HLA‐DRB1 *11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27–1.93, p = 2.70e‐05). We also discovered associations between iRBD and HLA‐DRB1 70D (OR = 1.26, 95%CI = 1.12–1.41, p = 8.76e‐05), 70Q (OR = 0.81, 95%CI = 0.72–0.91, p = 3.65e‐04) and 71R (OR = 1.21, 95%CI = 1.08–1.35, p = 1.35e‐03). Position 71 ( p omnibus = 0.00102) and 70 ( p omnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.
