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Disrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity

Archive ouverte | Donada, Alessandro | CCSD

International audience. Abstract Filamin A (FLNa) links the cell membrane with the cytoskeleton and is central in several cellular processes. Heterozygous mutations in the X-linked FLNA gene are associated with a la...

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

Archive ouverte | Antony-Debré, Iléana | CCSD

International audience. A half loss of RUNX1 activity leads to defects in primitive erythropoiesis, megakaryopoiesis, and proplatelet formation. • An almost complete loss of RUNX1 activity leads to the amplification...

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis

Archive ouverte | Basso-Valentina, Francesca | CCSD

International audience. Sustained ANKRD26 expression associated with germline ANKRD26 mutations causes thrombocytopenia 2 (THC2), an inherited platelet disorder associated with a predisposition to leukemia. Some pat...

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