Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials
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Aparicio, Thomas | Ducreux, Michel | Faroux, Roger | Barbier, Emilie | Manfredi, Sylvain | Lecomte, Thierry | Etienne, Pierre-Luc | Bedenne, Laurent | Bennouna, Jaafar | Phelip, Jean-Marc | François, Eric | Michel, Pierre | Legoux, Jean-Louis | Gasmi, Mohamed | Breysacher, Gilles | Rougier, Philippe | de Gramont, Aimery | Lepage, Côme | Bouché, Olivier | Seitz, Jean-François | Adenis, A | Alessio, A | Aouakli, A | Azzedine, A | Bedjaoui, A | Bidault, A | Blanchi, A | Botton, A | Cadier-Lagnes, A | Fatisse, A | Gagnaire, A | Gilbert, A | Gueye, A | Hollebecque, A | Lemaire, A | Mahamat, A | Marre, A | Patenotte, A | Rotenberg, A | Roussel, A | Thirot-Bidault, A | Votte, A | Weber, A | Zaanan, A | Dupont-Gossart, A, C | Villing, A, L | Queuniet, A, M | Coudert, B | Denis, B | Garcia, B | Lafforgue, B | Landi, B | Leduc, B | Linot, B | Paillot, B | Rhein, B | Winkfield, B | Barberis, C | Becht, C | Belletier, C | Berger, C | Bineau, C | Borel, C | Brezault, C | Buffet, C | Cornila, C | Couffon, C | de la Fouchardière, C | Giraud, C | Lecaille, C | Lepere, C | Lobry, C | Locher, C | Lombard-Bohas, C | Paoletti, C | Platini, C | Rebischung, C | Sarda, C | Vilain, C | Briac-Levaché, C | Auby, D | Baudet-Klepping, D | Bechade, D | Besson, D | Cleau, D | Festin, D | Gargot, D | Genet, D | Goldfain, D | Luet, D | Malka, D | Peré-Vergé, D | Pillon, D | Sevin-Robiche, D | Smith, D | Soubrane, D | Tougeron, D | Zylberait, D | Carola, E | Cuillerier, E | Dorval Danquechin, E | Echinard, E | Janssen, E | Maillard, E | Mitry, E | Norguet-Monnereau, E | Suc, E | Terrebonne, E | Zrihen, E | Pariente, E, A | Almaric, F | Audemar, F | Bonnetain, F | Desseigne, F | Dewaele, F | Di Fiore, F | Ghiringhelli, F | Husseini, F | Khemissa, F | Kikolski, F | Morvan, F | Petit-Laurent, F | Riot, F | Subtil, F | Zerouala-Boussaha, F | Caroli-Bosc, F, X | Boilleau-Jolimoy, G | Bordes, G | Cavaglione, G | Coulanjon, G | Deplanque, G | Gatineau-Saillant, G | Goujon, G | Medinger, G | Roquin, G | Brixi-Benmansour, H | Castanie, H | Lacroix, H | Maechel, H | Perrier, H | Salloum, H | Senellart, H | Baumgaertner, I | Cumin, I | Graber, I | Trouilloud, I | Boutin, J | Butel, J | Charneau, J | Cretin, J | Dauba, J | Deguiral, J | Egreteau, J | Ezenfis, J | Forestier, J | Goineau, J | Lacourt, J | Lafon, J | Martin, J | Meunier, J | Moreau, J | Provencal, J | Taieb, J | Thaury, J | Tuaillon, J | Vergniol, J | Villand, J | Vincent, J | Volet, J | Bachet, J, B | Barbare, J, C | Souquet, J, C | Grangé, J, D | Dor, J, F | Paitel, J, F | Jouve, J, L | Raoul, J, L | Cheula, J, M | Gornet, J, M | Sabate, J, M | Vantelon, J, M | Vaillant, J, N | Aucouturier, J, P | Barbieux, J, P | Herr, J, P | Lafargue, J, P | Lagasse, J, P | Latrive, J, P | Plachot, J, P | Ramain, J, P | Robin, J, P | Spano, J, P | Douillard, J, Y | Beerblock, K | Bouhier-Leporrier, K | Slimane Fawzi, K | Cany, L | Chone, L | Dahan, L | Gasnault, L | Rob, L | Stefani, L | Wander, L | Baconnier, M | Ben Abdelghani, M | Benchalal, M | Blasquez, M | Carreiro, M | Charbit, M | Combe, M | Duluc, M | Fayolle, M | Gignoux, M | Giovannini, M | Glikmanas, M | Mabro, M | Mignot, M | Mornet, M | Mousseau, M | Mozer, M | Pauwels, M | Pelletier, M | Porneuf, M | Ramdani, M | Schnee, M | Tissot, M | Zawadi, M | Clavero-Fabri, M, C | Gouttebel, M, C | Kaminsky, M, C | Galais, M, P | Abdelli, N | Barrière, N | Bouaria, N | Bouarioua, N | Delas, N | Gérardin, N | Hess-Laurens, N | Stremsdoerfer, N | Berthelet, O | Boulat, O | Capitain, O | Favre, O | Amoyal, P | Bergerault, P | Burtin, P | Cassan, P | Chatrenet, P | Chiappa, P | Claudé, P | Couzigou, P | Feydy, P | Follana, P | Geoffroy, P | Godeau, P | Hammel, P | Laplaige, P | Lehair, P | Martin, P | Novello, P | Pantioni, P | Pienkowski, P | Pouderoux, P | Prost, P | Ruszniewski, P | Souillac, P | Texereau, P | Thévenet, P | Haineaux, P, A | Benoit, R | Coriat, R | Lamy, R | Mackiewicz, R | Beorchia, S | Chaussade, S | Hiret, S | Jacquot, S | Lavau Denes, S | Montembault, S | Nahon, S | Nasca, S | Nguyen, S | Oddou-Lagraniere, S | Pesque-Penaud, S | Fratte, S, P | Chatellier, T | Mansourbakht, T | Morin, T | Walter, T | Boige, V | Bourgeois, V | Derias, V | Guérin-Meyer, V | Hautefeuille, V | Jestin Le Tallec, V | Lorgis, V | Quentin, V | Sebbagh, V | Veuillez, V | Adhoute, X | Coulaud, X | Becouarn, Y | Coscas, Y | Courouble, Y | Le Bricquir, Y | Molin, Y | Rinaldi, Y | Lam, Y, H | Ladhib, Z
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CCSD ; Elsevier -
International audience.
Background: Previous studies showed that high and low body mass index (BMI) was associated with worse prognosis in early-stage colorectal cancer (CRC), and low BMI was associated with worse prognosis in metastatic CRC (mCRC). We aimed to assess efficacy outcomes according to BMI.Patients and methods: A pooled analysis of individual data from 2085 patients enrolled in eight FFCD first-line mCRC trials from 1991 to 2013 was performed. Comparisons were made according to the BMI cut-off: Obese (BMI ≥30), overweight patients (BMI ≥ 25), normal BMI patients (BMI: 18.5-24) and thin patients (BMI <18.5). Interaction tests were performed between BMI effect and sex, age and the addition of antiangiogenics to chemotherapy.Results: The rate of BMI ≥25 patients was 41.5%, ranging from 37.6% (1991-1999 period) to 41.5% (2000-2006 period) and 44.8% (2007-2013 period). Comparison of overweight patients versus normal BMI range patients revealed a significant improvement of median overall survival (OS) (18.5 versus 16.3 months, HR = 0.88 [0.80-0.98] p = 0.02) and objective response rate (ORR) (42% versus 36% OR = 1.23 [1.01-1.50] p = 0.04) but a comparable median progression-free survival (PFS) (7.8 versus 7.2 months, HR = 0.96 [0.87-1.05] p = 0.35). Subgroup analyses revealed that overweight was significantly associated with better OS in men. OS and PFS were significantly shorter in thin patients.Conclusion: Overweight patients had a prolonged OS compared with normal weight patients with mCRC. The association of overweight with better OS was only observed in men. The pejorative prognosis of BMI <18.5 was confirmed.
