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Kinetics of plasma Apolipoprotein E isoforms by LC-MS/MS: a pilot study

Archive ouverte | Blanchard, Valentin | CCSD

International audience. Human apolipoprotein E (apoE) exhibits three major isoforms (apoE2, apoE3, and apoE4) corresponding to polymorphism in theAPOEgene. Total plasma apoE concentrations are closely related to the...

VLDL (Very-Low-Density Lipoprotein)-Apo E (Apolipoprotein E) May Influence Lp(a) (Lipoprotein [a]) Synthesis or Assembly

Archive ouverte | Croyal, Mikaël | CCSD

International audience. OBJECTIVE: To clarify the association between PCSK9 (proprotein convertase subtilisin/kexin type 9) and Lp(a) (Lipoprotein [a]), we studied Lp(a) kinetics in patients with loss-of-function an...

PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate

Archive ouverte | Croyal, Mikaël | CCSD

International audience. Therapeutic antibodies targeting proprotein convertase subtilisin kexin type 9 (PCSK9) (e.g. alirocumab) lower low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp(a)] levels i...

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