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A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

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Muczynski, Vincent | Casari, Caterina | Moreau, François | Aymé, Gabriel | Kawecki, Charlotte | Legendre, Paulette | Proulle, Valerie | Christophe, Olivier | Denis, Cécile | Lenting, Peter, J.

Edité par CCSD ; American Society of Hematology -

International audience. Key Points The fusion between FVIII and anti-VWF nanobodies increases affinity for VWF 25-fold without compromising FVIII activity. Stabilized VWF binding results in a twofold enhanced circulatory survival of FVIII and reduced anti-FVIII antibody formation.

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