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Alternative PDGFD rearrangements in dermatofibrosarcomas protuberans without PDGFB fusions

Archive ouverte | Dadone-Montaudié, Bérengère | CCSD

International audience. Dermatofibrosarcoma protuberans is underlined by recurrent collagen type I alpha 1 chain-platelet-derived growth factor B chain (COL1A1-PDGFB) fusions but ~ 4% of typical dermatofibrosarcoma ...

Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas.

Archive ouverte | Italiano, Antoine | CCSD

International audience. PURPOSE: The MDM2 and HMGA2 genes are consistently amplified in well-differentiated/dedifferentiated liposarcomas (WDLPS/DDLPS) whereas CDK4 is frequently but not always amplified in these tu...

HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.

Archive ouverte | Italiano, Antoine | CCSD

Data concerning the fine structure of the 12q13-15 amplicon which contains MDM2 and CDK4 in well-differentiated and dedifferentiated liposarcomas (WDLPS/DDLPS) are scarce. We investigated a series of 38 WDLPS/DDLPS using fluoresce...

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