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Efficient gene delivery and silencing of mouse and human pancreatic islets

Archive ouverte | Lefebvre, Bruno | CCSD

International audience. Background: In view of the importance of beta cells in glucose homeostasis and the profound repercussions of beta cell pathology on human health, the acquisition of tools to study pancreatic ...

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

Archive ouverte | Ploton, Maheul | CCSD

Maheul Ploton and Claire Mazuy contributed equally to this study.. International audience. The nuclear bile acid receptor FXR is a PKA-and FOXA2-sensitive activator of fasting hepatic gluconeogenesis Graphical abstr...

Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic β‐cells

Archive ouverte | Mazuy, Claire | CCSD

International audience. Nur77 is a stress sensor in pancreatic β‐cells, which negatively regulates glucose‐stimulated insulin secretion. We recently showed that a lipotoxic shock caused by exposure of β‐cells to the...

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