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Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure

Archive ouverte | Lépine, Matthieu | CCSD

International audience. Background: Perineuronal nets (PNNs) are specialized extracellular matrix structures mainly found around fastspiking parvalbumin (FS-PV) interneurons. In the adult, their degradation alters F...

Two-Chains Tissue Plasminogen Activator Unifies Met and NMDA Receptor Signalling to Control Neuronal Survival

Archive ouverte | Hedou, Elodie | CCSD

International audience. Tissue-type plasminogen activator (tPA) plays roles in the development and the plasticity of the nervous system. Here, we demonstrate in neurons, that by opposition to the single chain form (...

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury

Archive ouverte | Lemarchant, Sighild | CCSD

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